Medizinische Universität Graz Austria - Forschungsportal - Medical University of Graz
PREGENESYS: Development of Early Non-Invasive Biomarkers and Means for the Diagnosis and Progression Monitoring of Preeclampsia and Tailoring Putative Therapies
- Abstract
- Preeclampsia (PET), de-novo hypertension & proteinuria after mid gestation, affects 5-7% of all pregnancies. Cases may develop life threatening haemolysis-elevated liver enzymes-low platelets (HELLP) or renal failure, cerebral haemorrhages & eclampsia, IUGR, placental abruption & death.
We will identify markers for PET risk prediction in the 1st trimester to allow longer time for tailoring putative medications to prevent PET, and assess & characterize plausible links between marker shortage/access, PET & putative medications in "in-vitro" systems to fit putative medications to pre-defined disease-risk women.
We will develop non-invasive diagnostic kits for 1st trimester PET prediction based on markers, antibodies, oligos & siRNA and others coupled to the power of Doppler ultrasound. Nested case-control clinical studies will test effectiveness of combined diagnosis & drug tailoring. A Trans European prospective clinical study, combining early diagnosis & randomising putative medication will verify findings.
R&D results will be used to train physicians & patients, to implement new prenatal care practice and eradicate preeclampsia.
- Projektleitung:
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Huppertz Berthold
- Laufzeit:
- 01.12.2006-30.11.2009
- Programm:
- EU (FP-6)
- Subprogramm
- Biowissenschaften (4. Ausschreibung, Einreichfrist 9.11.2005)
- EU-Projektinstrument
- Spec. Target. o Inn. Project (STREP)
- Art der Forschung
- Grundlagenforschung
- Mitarbeiter/innen
- Huppertz B., Projektleiter/in
- Scheiber B., Projektmitarbeiter/in
- Beteiligte MUG-Organisationseinheiten
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Institut für Zellbiologie, Histologie und Embryologie
- Projektpartner
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Barking, Havering & Redbridge Hospitals NHS Trust, Romford, Großbritannien.
Kontaktperson: Prof. Kevin Spencer;
-
Diagnostic Technologies, Haifa, Israel.
Kontaktperson: Dr. Hamutal Meiri;
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Fetal Medicine Foundation, London, Großbritannien.
Kontaktperson: Prof. Kypros H Nicolaides;
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Global Research & Financing, Tel Aviv, Israel.
Kontaktperson: Prof. Zohar Ben-Asher;
-
ImmunoSTAR, Porto, Portugal.
Kontaktperson: Pedro Seada;
-
Semmelweis University Budapest, Budapest, Ungarn.
Kontaktperson: Dr. Nandor Gabor Than;
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University of Basel, Basel, Schweiz.
Kontaktperson: Prof. Sinuhe Hahn;
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University of Milan, Milan, Italien.
Kontaktperson: Prof. Irene Cetin;
-
Wallac, Turko, Finnland.
Kontaktperson: Yvonne Parker;
- Gefördert durch
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Europäische Kommission, Rue de la Loi, Brussels, Europäische Union
