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SHR Neuro Krebs Kardio Lipid

Koestenberger, M; Hansmann, G; Apitz, C; Latus, H; Lammers, A.
Diagnostics in Children and Adolescents with Suspected or Confirmed Pulmonary Hypertension
PAEDIATR RESPIR REV. 2017; 23: 3-15.
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Köstenberger Martin
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Abstract:
We provide a practical approach on the initial assessment and diagnostic work-up of children and adolescents with pulmonary hypertension (PH). Transthoracic echocardiography (TTE) often serves as initial study tool before invasive cardiac catheterization. Misinterpretation of TTE variables may lead to missed or delayed diagnosis with devastating consequences, or unnecessary invasive diagnostics that have inherited risks. In addition to clinical and biochemical markers, serial examination of patients with PH using a standardized TTE approach, determining conventional and novel echocardiographic variables, may allow early diagnosis and treatment in paediatric PH. Cardiac magnetic resonance imaging and computed tomography represent important non-invasive imaging modalities, that together with TTE may enable comprehensive assessment of ventricular function and pulmonary hemodynamics. Invasive assessment of haemodynamics (ventricular, pulmonary) and testing of acute vasoreactivity in the catheterization laboratory is still the gold standard for the diagnosis of PH and pulmonary hypertensive vascular disease (PHVD) in children and for the initiation of specific PH therapy. We suggest the regular assessment of prognostic TTE variables as part of a standardized approach for initial diagnosis of children with PH. Overreliance on any single TTE variable should be avoided as it detracts from the overall diagnostic potential of a standardized TTE examination for PH. (C) 2016 Published by Elsevier Ltd.

Find related publications in this database (Keywords)
diagnostic features
echocardiography
pediatric pulmonary hypertension
cardiac magnetic resonance imaging
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