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SHR Neuro Krebs Kardio Lipid

Basu, A; Pieber, TR; Hansen, AK; Sach-Friedl, S; Erichsen, L; Basu, R; Haahr, H.
Greater early postprandial suppression of endogenous glucose production and higher initial glucose disappearance is achieved with fast-acting insulin aspart compared to insulin aspart.
Diabetes Obes Metab. 2018;
PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Pieber Thomas
Sach-Friedl Stefanie

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Plum Analytics:
Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with accelerated initial absorption after subcutaneous administration, leading to improved postprandial glucose control versus IAsp. We investigated the mechanisms behind the reduced postprandial glucose with faster aspart versus IAsp. In a randomised, double-blind, crossover trial, 41 subjects with type 1 diabetes received identical subcutaneous single faster aspart and IAsp doses (individualised for each subject) together with a standardised mixed meal (including 75 g carbohydrate labelled with [1-13C] glucose). Postprandial glucose turnover was determined by the triple-tracer meal method using continuous, variable [6-3H] glucose and [6,6-2H2] glucose infusion. Insulin exposure within the first hour was 32% greater for faster aspart versus IAsp (treatment ratio faster aspart/IAsp [95% confidence interval] 1.32 [1.18;1.48], p<0.001), leading to a 0.59 mmol/L non-significantly smaller postprandial glucose increment at 1 hour (ΔPG1h; treatment difference faster aspart-IAsp [95% confidence interval] -0.59 mmol/L [-1.19;0.01], p=0.055). The trend towards reduced ΔPG1hwith faster aspart was due to 12% greater suppression of endogenous glucose production (treatment ratio 1.12 [1.01;1.25], p=0.040) and 23% higher glucose disappearance (1.23 [1.05;1.45], p=0.012) with faster aspart versus IAsp during the first hour. Suppression of free fatty acid levels during the first hour was 36% greater for faster aspart versus IAsp (1.36 [1.01;1.88], 0.042). The trend towards improved postprandial glucose control with faster aspart versus IAsp in this study was due to both greater early suppression of endogenous glucose production and stimulation of glucose disappearance. This article is protected by copyright. All rights reserved.

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