Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Clementi, M; Tenconi, R; Bianchi, F; Stoll, C.
Evaluation of prenatal diagnosis of cleft lip with or without cleft palate and cleft palate by ultrasound: experience from 20 European registries. EUROSCAN study group.
Prenat Diagn. 2000; 20(11):870-875
Web of Science PubMed FullText


Study Group Mitglieder der Med Uni Graz:
Haeusler Martin

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Plum Analytics:
Ultrasound scans in the mid-trimester of pregnancy are now a routine part of antenatal care in most European countries. Using data from registries of congenital anomalies a study was undertaken in Europe. The objective of the study was to evaluate prenatal detection of cleft lip with or without cleft palate (CL(P)) and cleft palate (CP). All CL(P) and CPs suspected prenatally and identified at birth in the period 1996-98 were registered from 20 Congenital Malformation Registers from the following European countries: Austria, Croatia, Denmark, France, Germany, Italy, Lithuania, Spain, Switzerland, The Netherlands, UK, Ukraine. These registries followed the same methodology. A total of 709,027 births were covered; 7758 cases with congenital malformations were registered. Included in the study were 751 cases reported with facial clefts: 553 CL(P) and 198 CP. The prenatal diagnosis by transabdominal ultrasound of CL(P) was made in 65/366 cases with an isolated malformation, in 32/62 cases with chromosomal anomaly, in 30/89 cases with multiple malformations and in 21/36 syndromic cases. The prenatal diagnosis of CP was made in 13/198 cases. One hundred pregnancies were terminated (13%); in 97 of these the cleft was associated with other malformations.
Find related publications in this database (using NLM MeSH Indexing)
Cleft Lip - complications
Cleft Palate - complications
Europe - epidemiology
Gestational Age - epidemiology
Registries - epidemiology
Ultrasonography, Prenatal - epidemiology

Find related publications in this database (Keywords)
cleft lip
cleft palate
prenatal diagnosis
birth defects
ultrasound screening
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