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Fasching, G; Haeusler, M; Mayr, J; Schimpl, G; Haas, J; Puerstner, P.
Can levels of interleukins and matrix metalloproteinases in the amniotic fluid predict postnatal bowel function in fetuses with gastroschisis?
J PEDIAT SURG. 2005; 40(12): 1887-1891.
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Autor/innen der Med Uni Graz:
Haas Josef
Haeusler Martin
Mayr Johannes
Puerstner Peter
Schimpl Günther
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Abstract:
Purpose: The aim of this study was to determine whether interleukin or matrix metalloproteinase (MMP) levels in the amniotic fluid call predict the postnatal condition of the bowel in fetuses with gastroschisis (GS). Methods: Eleven pregnant women with a fetus with GS underwent amniocentesis. Levels of IL-1 alpha, IL-1 beta, and IL-6 were measured in 10 of 11 specimens, and MMP-1 MMP-3. and MMP-8 levels were measured in 7 of 11 specimens. Neonates who tolerated complete oral feeding within 21 days were considered to have good bowel status (GS/good: n = 4, 4 in interleukin study or 3 in MMP study); those who did not were considered to have poor bowel status (GS/poor: n = 7, 6 in interleukin study or 4 in MMP study). Seventy-eight women undergoing amniocentesis for other reasons served as controls. Results: Interleukin-1 levels were considerably lower in the pregnancies complicated by GS than in controls. Matrix metalloproteinases 3 and 8 levels were significantly higher in the GS pregnancies than in controls. Neonates with poor bowel status had higher MMP-3 and MMP-8 levels than those with good bowel status. Conclusion: Amniotic fluid MMP-3 and MMP-8 levels may prove useful to assess the condition of the bowel in fetuses with GS. (c) 2005 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Amniocentesis -
Amniotic Fluid - chemistry
Biological Markers - analysis
Collagen - metabolism
Female -
Gastroschisis - complications Gastroschisis - pathology
Humans -
Infant, Newborn -
Interleukin-1 - analysis
Intestines - physiology
Male -
Matrix Metalloproteinase 3 - analysis
Matrix Metalloproteinase 8 - analysis
Predictive Value of Tests -
Pregnancy -
Pregnancy Complications -
Prognosis -

Find related publications in this database (Keywords)
gastroschisis
amniocentesis
cytokines
matrix metalloproteinases
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