Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Weger, M; Haas, A; Stanger, O; El-Shabrawi, Y; Temmel, W; Maier, R; Berghold, A; Haller-Schober, EM.
Chlamydia pneumoniae seropositivity and the risk of nonarteritic ischemic optic neuropathy.
OPHTHALMOLOGY 2002 109: 749-752.
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Berghold Andrea
El-Shabrawi Yosuf
Haas Anton
Haller-Schober Eva-Maria
Maier Richard
Temmel Werner
Weger Martin
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Abstract:
OBJECTIVE: To determine whether IgG antibodies to Chlamydia pneumoniae are associated with nonarteritic ischemic optic neuropathy (NAION). DESIGN: Retrospective case-control study. PARTICIPANTS: The study cohort consisted of 71 consecutive patients with NAION and 71 controls matched for age and gender. MAIN OUTCOME MEASURES: Serum immunoglobulin G (IgG) antibody titers to Chlamydia pneumoniae. RESULTS: Patients with NAION had significantly higher IgG antibody titers to C. pneumoniae compared with control subjects (IgG titer > or =1:128: 29 patients versus 15 controls, P = 0.017). The odds ratio for patients with an IgG titer > or =1:128 was 2.56 (95% confidence interval [CI], 1.2-5.5). Adjustment for arterial hypertension, diabetes mellitus, and myocardial infarction resulted in an odds ratio of 3.48 (95% CI, 1.3-9.6). CONCLUSIONS: Our results suggest that elevated titers of IgG antibodies to C. pneumoniae are associated with NAION.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Antibodies, Bacterial - blood
Case-Control Studies - blood
Chlamydophila Infections - blood
Chlamydophila pneumoniae - immunology
Eye Infections, Bacterial - blood
Female - blood
Humans - blood
Immunoglobulin G - blood
Male - blood
Middle Aged - blood
Odds Ratio - blood
Optic Neuropathy, Ischemic - blood
Retrospective Studies - blood
Risk Factors - blood

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