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Langsenlehner, T; Langsenlehner, U; Renner, W; Kapp, KS; Krippl, P; Hofmann, G; Clar, H; Pummer, K; Mayer, R.
The Glu228Ala polymorphism in the ligand binding domain of death receptor 4 is associated with increased risk for prostate cancer metastases.
Prostate. 2008; 68(3):264-268
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Autor/innen der Med Uni Graz:
Clar Heimo
Hofmann Günter
Kapp Karin S.
Langsenlehner Tanja
Langsenlehner Uwe
Mayer Ramona
Pummer Karl
Renner Wilfried
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Abstract:
BACKGROUND: Death receptor 4, encoded by the TNFRSF10A gene, is an important mediator of apoptosis and its dysfunction may be related to cancer development and distant tumor spread. A single nucleotide polymorphism in TNFRSF10A (Glu228Ala, rs20576) within a conserved region of the extracellular cysteine-rich domain of death receptor 4 has been associated with an increased risk for a variety of tumor entities. Aim of the present study was to evaluate the role of the TNFRSF10A polymorphism in metastatic progression of prostate cancer after radiation therapy. METHODS: We carried out a prospective study including 702 prostate cancer patients from the Austrian PROCAGENE (Prostate Cancer Genetics) study. Development of metastases was examined in regular follow-up investigations. TNFRSF10A genotypes were determined by a 5'-nuclease assay (TaqMan). RESULTS: Within a median follow-up time of 10 months (range 0-60 months), 24 (3.4%) patients developed metastases. In a Cox regression model including age at diagnosis and risk group as potential confounders, carriage of an 228Ala allele was associated with a relative risk of 2.47 (95% CI 1.10-5.54; P=0.028) for metastases. TNFRSF10A genotypes were not associated with tumor stage, grade, risk group or age at diagnosis. CONCLUSION: We conclude that the TNFRSF10A Glu228Ala polymorphism may be a novel independent risk factor for prostate cancer metastases after radiation therapy.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Austria -
Cohort Studies -
Cross-Sectional Studies -
DNA, Neoplasm - chemistry
Genotype -
Humans -
Kaplan-Meiers Estimate -
Ligands -
Male -
Neoplasm Metastasis -
Polymerase Chain Reaction -
Polymorphism, Single Nucleotide -
Proportional Hazards Models -
Prospective Studies -
Prostatic Neoplasms - genetics
Protein Structure, Tertiary -
Receptors, Tumor Necrosis Factor - genetics

Find related publications in this database (Keywords)
prostate cancer metastases
prognostic factors
apoptosis
death receptor 4
single nucleotide polymorphisms
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