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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Bohlig, L; Metzger, R; Rother, K; Till, H; Engeland, K.
The CCN3 gene coding for an extracellular adhesion-related protein is transcriptionally activated by the p53 tumor suppressor
Cell Cycle. 2008; 7(9):1254-1261 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Till Holger
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Abstract:
The CCN3 protein (Nov, Nephroblastoma overexpressed) is a member of the CCN family (Cyr61, CTGF, Nov) of growth regulators and exerts antiproliferative properties. We show here that the tumor suppressor p53 transcriptionally upregulates the CCN3 gene. p53 is an important transcription factor contributing to cell cycle arrest and apoptosis after cell damage through the regulation of numerous target genes. We show that CCN3 mRNA and protein are upregulated following p53 expression. A DNA binding-deficient p53 mutant fails to regulate CCN3. CCN3 protein is located in the perinuclear space after induction and is also exported to the extracellular matrix. Furthermore, the CCN3 promoter is inducible by p53 and the response element is located in the first exon of the CCN3 gene. Chromatin immunoprecipitations show that p53 binds to the CCN3 promoter in vivo. As CCN3 was shown to inhibit cell growth, transcriptional induction by p53 may serve as an antiproliferative signal in the extracellular matrix. Furthermore, CCN3 depletion was also reported to reduce collagen type IV-dependent adhesion of melanocytes. Thus, elevated levels of CCN3 protein regulated by p53 might influence cell adhesion.
Find related publications in this database (using NLM MeSH Indexing)
Cell Adhesion - genetics
Cell Line, Tumor -
Cell Proliferation -
Collagen Type IV - metabolism
Connective Tissue Growth Factor -
Extracellular Matrix - metabolism
Gene Expression Regulation - genetics
Humans -
Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism
Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism
Neoplasm Invasiveness - genetics Neoplasm Invasiveness - physiopathology
Nephroblastoma Overexpressed Protein -
Promoter Regions, Genetic - genetics
Protein Binding - genetics
RNA, Messenger - metabolism
Transcriptional Activation - genetics
Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
Up-Regulation - genetics

Find related publications in this database (Keywords)
CCN3
nov
p53 tumor suppressor
transcription
extracellular matrix
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