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SHR Neuro Krebs Kardio Lipid

Finkenstedt, A; Auer, C; Glodny, B; Posch, U; Steitzer, H; Lanzer, G; Pratschke, J; Biebl, M; Steurer, M; Graziadei, I; Vogel, W; Zoller, H.
Patatin-like phospholipase domain-containing protein 3 rs738409-G in recipients of liver transplants is a risk factor for graft steatosis.
Clin Gastroenterol Hepatol. 2013; 11(12):1667-1672
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Autor/innen der Med Uni Graz:
Lanzer Gerhard
Posch Ursula
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Abstract:
The G-allele in position rs738409 of patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with an increased hepatic concentration of triglyceride and is a risk factor for advanced liver disease. We investigated the association of donor and recipient risk alleles with the development of graft steatosis after liver transplantation. PNPLA3 genotypes were determined in 237 transplant recipients and in 255 organ donors. Macrovesicular steatosis was assessed by unenhanced computed tomography 5 years after liver transplantation in 95 patients and correlated with donor and recipient PNPLA3 genotype. The risk allele was significantly more frequent in transplant recipients than in donors (42% vs 28%; P < .001). A prevalence of graft steatosis of 30% or greater significantly increased from 11.6% at 1 year after liver transplantation to 32.6% at 5 years after transplantation. Five years after liver transplantation, steatosis was present in 63.2% of patients homozygous for the rs738409-G allele, in 31.4% of heterozygous recipients, and in 12.0% of rs738409-CC recipients (P = .002). Donor genotypes were not associated with the development of graft steatosis. In multivariate regression analysis, recipients who carried rs738409-GG had a 13.7-fold higher risk of graft steatosis than recipients who carried rs738409-CC (P = .022), independent of recipient age, weight gain after liver transplantation, or the underlying disease. Liver transplant recipients who carry rs738409-G in PNPLA3 are at increased risk for hepatic triglyceride accumulation, independent of the graft PNPLA3 genotype. Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Fatty Liver - genetics
Female -
Genotype -
Genotyping Techniques -
Humans -
Lipase - genetics
Liver - pathology
Liver Transplantation -
Male -
Membrane Proteins - genetics
Middle Aged -
Polymorphism, Single Nucleotide -
Retrospective Studies -
Risk Factors -
Tomography, X-Ray Computed -
Transplantation -

Find related publications in this database (Keywords)
Genetics
Nonalcoholic Fatty Liver Disease
Alcoholic Liver Disease
Variant
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